Effects of diazepam and of serotonin agonists on hyponeophagia in rats.
Neuropharmacology April 1, 1982 Peer reviewed DOI: 10.1016/0028-3908(82)90097-1 via PubMed
Summary
Serotonin agonists significantly increased hyponeophagia in male and female rats, with fenfluramine (2 mg/kg) and 5-methoxy N,N dimethyltryptamine (2.5 mg/kg) showing notable effects. In contrast, diazepam (1 mg/kg) reduced hyponeophagia and counteracted the actions of both serotonin agonists. This suggests that diazepam operates differently from serotonergic drugs regarding hyponeophagia. The findings highlight the complex interactions between these substances and contribute to understanding the serotonin hypothesis related to benzodiazepine action, emphasizing the distinct role of diazepam.
Abstract
The effects of serotonin agonists, fenfluramine (2 mg/kg) and 5-methoxy N,N dimethyltryptamine (5-MeODMT, 2.5 mg/kg) on hyponeophagia were studied both alone and in combination with diazepam (1 mg/kg). Male and female rats were used but sex differences were not found. The serotonin agonists enhanced hyponeophagia while diazepam attenuated it and antagonised the actions of both serotonin agonists. These findings are discussed in connection with the serotonin hypothesis of benzodiazepine action with the conclusion that diazepam acts distally to serotonergic drugs on hyponeophagia.