Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for systematic review and meta-analysis.
Michele F Rodrigues, Larissa Junkes, Jose Appolinario, Antonio E Nardi
PloS one January 1, 2024 DOI: 10.1371/journal.pone.0306227
Summary
Mindfulness-Based Cognitive Therapy (MBCT) shows promise for individuals with Treatment-Resistant Depression (TRD), a condition affecting approximately 30% of those diagnosed with Major Depressive Disorder. This systematic review will analyze randomized clinical trials and quasi-experimental studies, examining the effectiveness of MBCT compared to standard care in reducing depressive symptoms. The search includes comprehensive database reviews and manual screenings, aiming to assess both efficacy and safety. The findings could significantly impact treatment options for the estimated 1 in 10 adults facing TRD challenges.
Abstract
Major Depressive Disorder (MDD) is a global health issue, and a significant portion of individuals with MDD experience Treatment-Resistant Depression (TRD), characterized by the lack of response to adequately trialed antidepressant medication and therapy. This systematic review aims to investigate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) as an intervention for individuals with TRD. We will conduct a thorough search for publications of randomized clinical trials and quasi-experimental studies in MEDLINE, Embase, PsycINFO, Web of Science databases, and ClinicalTrials.gov. Furthermore, reference lists of included studies will be manually screened for additional relevant articles, with no restrictions on language or publication date. The search will be conducted from the inception of the databases until June 2024. Our PICO-guided research questions are: (1) In adults with Treatment-Resistant Depression, is MBCT more effective than standard care or other active treatments in reducing depressive symptoms? (2) In adults with Treatment-Resistant Depression, does MBCT demonstrate a comparable safety profile to standard care or other active treatments? The quality of the included studies will be assessed independently using the Cochrane Risk of Bias Tool (RoB 2). This study seeks to evaluate the effectiveness and tolerability of Mindfulness-Based Cognitive Therapy as an intervention for Treatment-Resistant Depression, and will employ the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to appraise the confidence in the evidence. Prospero registration ID: CRD42023411978. Registered on April 07, 2023.