Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects
bioRxiv February 8, 2025 preprint DOI: 10.1101/2025.02.07.637042
Summary
Our brains respond uniquely to different psychedelic compounds. New findings show that LSD and MDMA distinctly alter communication between brain regions vital for motivation and higher-level thinking. Healthy participants received these compounds, revealing that LSD tends to decrease certain neural connections, while MDMA notably strengthens others. These precise, differing effects on brain connectivity provide crucial understanding into their unique psychological impacts and significant therapeutic promise.
Abstract
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects