Altered anterior default mode network dynamics in progressive multiple sclerosis
Giulia Bommarito, Anjali Tarun, Younes Farouj, Maria Giulia Preti, Maria Petracca, Amgad Droby, Mohamed Mounir El Mendili, Matilde Inglese, Dimitri Van de Ville
medRxiv Preprint Server November 26, 2020 preprint DOI: 10.1101/2020.11.26.20238923
Summary
Progressive multiple sclerosis (PMS) uniquely alters brain activity patterns, a new investigation shows. It explored how the brain’s "default mode network," active during rest, functions in PMS patients. Using advanced imaging, researchers positively identified distinct changes in the anterior part of this network. These specific functional alterations offer a deeper understanding of PMS's underlying mechanisms, paving the way for future advancements in managing the disease.
Abstract
Background Modifications in brain function remain relatively unexplored in progressive multiple sclerosis (PMS), despite their potential to provide new insights into the pathophysiology of this disease stage.