Extending ketamine's antidepressant effects.

Summary

A single dose of ketamine can rapidly relieve depression, but its effects typically fade within days. New findings show that activating a specific brain signaling pathway can extend ketamine's antidepressant benefits from days to weeks. By enhancing mTORC1 signaling in brain cells, researchers successfully prolonged ketamine's mood-lifting effects, offering hope for more lasting depression treatments.

Abstract

Boosting an intracellular signaling pathway preserves the antidepressant response to ketamine.

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