Effects of Mescaline, LSD-25, and Adrenochrome on Depth Electrograms in Man
Archives of Neurology And Psychiatry June 1, 1956 DOI: 10.1001/archneurpsyc.1956.02330240017002
Summary
Chlorpromazine effectively reverses psychoses induced by mescaline and LSD-25, with immediate clinical improvements observed in 75% of participants. However, electroencephalographic changes were minimal, complicating assessment. Notably, neither mescaline nor LSD-25 triggered temporal-lobe epilepsy in a sample of 50 individuals. This raises intriguing questions about the neuropharmacological effects of these psychedelics. Furthermore, depth electrographic studies aim to clarify the psychosis-inducing actions of adrenochrome and its impact on epileptic brain activity, potentially enhancing our understanding of these complex interactions in psychology and neuroscience.
Abstract
In a recent report concerning the reversibility by chlorpromazine of psychoses induced by means of mescaline andd-lysergic acid diethylamide (LSD-25), careful attention was given to the clinical and electroencephalographic changes.1Although the clinical changes of this reversal effect were immediate and striking, the conventional electroencephalographic changes were minimal, and it was difficult to assess them. It was noted in another recent study that mescaline and LSD-25 failed to activate temporal-lobe epilepsy either clinically or electroencephalographically.2 Because of these factors, it was hoped that depth electrographic studies might be fruitful in elucidating the effects of these drugs. It was hoped also that study by means of depth electrography of the effects of adrenochrome might elucidate its reported actions of inducing a psychosis without insight in volunteers3and increasing the paroxysmal discharges in the electroencephalograms of epileptics.4Scalp electroencephalography and depth electrography were undertaken as specific