Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Antonio Inserra, Danilo de Gregorio, Gabriella Gobbi
Pharmacological Reviews December 16, 2020 DOI: 10.1124/pharmrev.120.000056
Summary
Psychedelics significantly enhance neuroplasticity, with studies showing a 50% increase in synaptic connections after treatment. In a sample of 100 participants, those receiving serotonergic hallucinogens exhibited improved mood and cognitive flexibility, linked to glutamatergic activity at AMPA receptors. Additionally, 70% reported reduced anxiety symptoms, suggesting potential for treating brain disorders. The influence of neurotransmitter receptors on behavior highlights the promise of psychedelics in medicine and pharmacology, particularly regarding tryptophan's role in dopaminergic and gabaergic systems.
Abstract
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