Suppression of LSD-25 Effects in Rats by Steroids.
John R. Bergen, Donald M. Krus, Gregory Pincus
Experimental Biology and Medicine November 1, 1960 DOI: 10.3181/00379727-105-26073
Summary
Steroid hormones can significantly suppress behavior changes induced by LSD-25 in rats, with 14 out of 15 tested hormones showing effectiveness. Notably, estradiol was the only hormone that did not produce this effect. The findings suggest that the ability to counteract LSD-25 is not linked to specific molecular structures or hormonal potency. This highlights the complex interactions between hormones, such as estrogen and its metabolites, and their potential roles in pharmacology and endocrinology related to behavior modulation.
Abstract
A series of 15 steroid hormones and metabolites were tested for their effectiveness to suppress LSD-25 induced behavior changes in rats. All produced significant suppression (p<0.05) except estradiol. Ability to suppress LSD-25 action does not appear to be related to specific molecular groups or to hormonal potency.