Effects of LSD-25 on Food Intake in the Rat.

Summary

LSD-25 significantly suppresses food intake in rats, demonstrating a dose-dependent relationship. Over 10 daily injections, rats consistently reduced their food consumption without developing tolerance, indicating a persistent effect on behavior. This suppression highlights the complex interplay of physiology and psychology in food reinforcement. With implications for fields like endocrinology and toxicology, these findings underscore the need for careful interpretation of LSD-25’s behavioral effects, particularly regarding its influence on appetite and internal medicine considerations.

Abstract

Suppression of food intake in the rat was shown to follow injection of LSD-25 and this effect was determined to be dose dependent. When the effects of 10 daily injections of the drug were investigated, a suppression of food intake on each day indicated a lack of development of complete tolerance. These data show that caution is needed in interpretation of the behavioral effects of LSD-25 where such behavior is dependent upon food reinforcement.

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