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Possible psychedelic therapeutic mechanism.

Evan M Hess, Todd D Gould

Science (New York, N.Y.) February 17, 2023 DOI: 10.1126/science.adg2989

Summary

Psychedelics may work differently than previously thought - they can reach hidden serotonin receptors inside brain cells that natural serotonin cannot access. This unique ability could explain their powerful effects on mood, perception, and consciousness, offering new insights into their therapeutic potential for mental health treatment.

Abstract

Psychedelics act on intracellular serotonin receptors that are not accessible by serotonin alone.

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