Nootropic Candidates Inhibit Head-Twitches Induced by Mescaline in Mice.
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi, Yasuhiro Fujikawa, Showa Ueki
The Japanese Journal of Pharmacology January 1, 1992 DOI: 10.1254/jjp.59.419
Summary
Idebenone, minaprine, and nebracetam significantly reduced mescaline-induced head-twitches in mice, with idebenone showing effects at doses of 32 and 100 mg/kg. Cholinesterase inhibitors like physostigmine (0.32 mg/kg) also suppressed head-twitch responses. Overall, the study involved various nootropic candidates and highlighted that the cholinergic-activating properties of these substances might play a crucial role in mitigating the effects of mescaline. With sample sizes indicating a robust evaluation of these pharmacological interactions, this research adds valuable insights into potential treatments for neurodegenerative diseases and memory disorders.
Abstract
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.