Nootropic Candidates Inhibit Head-Twitches Induced by Mescaline in Mice
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi, Yasuhiro Fujikawa, Showa Ueki
The Japanese Journal of Pharmacology January 1, 1992 DOI: 10.1016/s0021-5198(19)35545-3
Summary
Idebenone significantly reduced mescaline-induced head-twitches in mice, with a notable decrease observed at doses of 32 mg/kg and 100 mg/kg. Similarly, minaprine (0.32–10 mg/kg) and nebracetam (100 mg/kg) also mitigated these effects. Cholinesterase inhibitors like tetrahydroaminoacridine (1 and 10 mg/kg), NIK-247 (10 and 18 mg/kg), and physostigmine (0.32 mg/kg) further suppressed head-twitch responses. These findings suggest that the cholinergic-activating properties of these nootropic candidates may play a crucial role in counteracting mescaline's effects on sensory and memory functions.
Abstract
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32–10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.