Psychedelics, Harm Reduction, and Life's Big Questions: Making Sense of Spirituality and Religion After the Journey
Anthropology of Consciousness August 27, 2025 Peer reviewed DOI: 10.1111/anoc.70010 via OpenAlex
Summary
Psychedelic use appears to enhance spiritual connection and resolve religious conflicts among members of a Southeastern U.S. integration group. Participants reported feeling a greater sense of spirituality, although some faced challenges like religious condemnation and difficulties in interpreting their experiences. The findings suggest that considering spirituality is essential when discussing the effects of psychedelics on mental health, as it may help reduce harm and maximize benefits.
Study at a glance
| Design | ethnographic study |
|---|---|
| Population | members of a psychedelic integration group in the Southeastern U.S. |
| Key finding | Psychedelic encounters helped some participants resolve religious conflicts and nearly all reported a greater sense of spiritual connection. |
Abstract
ABSTRACT The interplay between psychedelic use, mental health, and spiritual, religious, or ‘mystical’ experiences continues to be investigated through clinical research. While many studies focus on general mechanisms underlying these compounds, analysis of real‐life accounts from individuals is underrepresented. To fill that gap, this ethnographic study explores the question of how members of a psychedelic integration group in the Southeastern U.S. perceive the impact of psychedelics on their spiritual and religious outlook. Thematic analysis revealed that psychedelic encounters helped some to resolve religious conflicts, such as estrangement from religion or adverse religious associations, while nearly all reported a greater sense of spiritual connection. Noted challenges included perceived or actual religious condemnation of psychedelics, the absence of sought‐after experiences, and difficulties interpreting ineffable occurrences. Findings reinforce the need for attention to spirituality when addressing psychedelic use and mental health, arguing that doing so reduces harm and optimizes benefits.