Improving Outcomes in Psychedelic-Assisted Therapy for Opioid Addiction through Herbal Medicine
Matthew Halma, Joseph Varon, Sirjana Dhillon, Edgar Selem, Carlos Gracidas, R. Levy
Medical Research Archives January 1, 2025 Peer reviewed DOI: 10.18103/mra.v14i3.7337 via OpenAlex
Summary
Psychedelic therapies show promise in treating conditions like PTSD and substance use disorders, but their effectiveness heavily relies on the facilitator and administration context. Despite positive trial results, stigma from past legal prohibitions hampers acceptance in medicine. This review offers guidance for managing opioid addiction symptoms post-psychedelic use, highlighting herbal substances such as corydalis and saffron that may ease opioid withdrawal and contribute to addressing the opioid crisis.
Study at a glance
| Design | review |
|---|---|
| Population | individuals with opioid use disorder |
| Key finding | Herbal substances like corydalis and saffron may help alleviate symptoms of opioid withdrawal following psychedelic use. |
Abstract
Psychedelic therapies have emerged as a modality of treatment for several treatment resistant diseases, including post-traumatic stress disorder (PTSD), treatment resistant depression, substance use disorders, anxiety, and obsessive-compulsive disorders. Arguably more than with other therapies, their success is dependent on the facilitator and the context of the administration. Several programs have emerged to provide facilitators education, but the field is not an acknowledged part of medicine, and suffers from stigma due to historical legal prohibition, despite positive results in trials as well as patient testimony. Medicine has been wary to advocate for psychedelic medicine, given its seeming overturning of several implicit assumptions, such as the primacy of the experience, as opposed to the action of the pharmacological agent itself, on the therapeutic action. For the case of addiction medicine, facilitators are often not well poised to navigate the challenges of substance abstinence with their clients. This review presents a guide to the clinical management of opioid addiction symptoms following psychedelic use, to provide a more secure offramp for individuals with opioid use disorder. Several herbal substances, including corydalis, saffron, berberine, and nigella sativa, may help to alleviate symptoms of opioid withdrawal and may be helpful for drawing down the opioid crisis.