Dezocine versus esketamine as postoperative analgesia in women undergoing cesarean section.

Summary

New findings show esketamine outperforms dezocine for pain management after cesarean sections. In a comparison of 134 women using patient-controlled intravenous analgesia, those receiving esketamine reported significantly less pain and recovered faster. They also showed lower rates of postpartum depression, while experiencing no increase in side effects.

Abstract

The objective of this was to investigate the effect of esketamine as a postoperative analgesia in women undergoing caesarean section. A total of 134 patients were divided into two groups: 112 received esketamine and 22 received dezocine, based on their voluntary choice of analgesic drugs for patient-controlled intravenous analgesia (PCIA). The postoperative analgesic effects were compared between the two groups. The results showed that the visual analogue scale (VAS) scores at 12 and 24 hours post-operation were significantly lower in the esketamine group than in the dezocine group (P0.05). There was no significant difference in adverse reactions between the groups (P>0.05). The Edinburgh postnatal depression scale (EPDS) scores at 1 and 3 days after surgery were significantly higher than the preoperative scores in both groups (P<0.05); however, the EPDS scores were significantly lower in the esketamine group compared to the Dezocine group (P<0.05). We conclude that esketamine provides effective postoperative pain relief in women undergoing caesarean section patients without increasing adverse reactions, while it promotes recovery and reduces postpartum depression.

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