A new approach to tritium labelling; the synthesis of [3H]ibogaine
Herbert H. Seltman, Denise F. Odear, F. Ivy Carroll, Christopher D. Wyrick
Journal of the Chemical Society Chemical Communications January 1, 1992 Peer reviewed DOI: 10.1039/c39920001757 via OpenAlex
Summary
A new method has been developed for preparing tritium-labelled ibogaine, which is intended for pharmacological studies as a treatment for cocaine addiction. This method involves the ortho metallation of aryl compounds followed by an easy reduction of the carbon-metal bond.
Study at a glance
| Key finding | A novel method for tritiating aryl compounds to produce tritium labelled ibogaine has been established. |
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Abstract
Tritium labelled ibogaine, for pharmacological studies as an anti-addiction treatment for cocaine abuse, is prepared by a new method for the tritiation of aryl compounds involving ortho metallation followed by facile reduction of the carbon–metal bond.