Contribution of the Serotonin 5-HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress.
Neuropsychopharmacol Rep September 1, 2026 Peer reviewed DOI: 10.1002/npr2.70152 via PubMed
Summary
The study investigates how the serotonin 5-HT2A receptor influences the effects of psilocin on social behavior deficits in mice subjected to social defeat stress. It finds that targeting this receptor may enhance psilocin's therapeutic benefits for improving social interactions in these mice, suggesting a potential mechanism for treating social behavior issues related to stress.
Study at a glance
| Population | mice exposed to social defeat stress |
|---|---|
| Key finding | Targeting the serotonin 5-HT2A receptor may enhance psilocin's therapeutic effects on social behavior deficits in stressed mice. |
Abstract
Contribution of the Serotonin 5-HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress.