α2-Adrenergic receptor modulates 5-HT2A-mediated behavioral effects of MDMA and psilocybin in mice.
Mol Psychiatry July 7, 2026 Peer reviewed DOI: 10.1038/s41380-026-03713-1 via PubMed
Summary
The α2-adrenergic receptor influences the behavioral effects of MDMA and psilocybin, specifically those mediated by the 5-HT2A receptor in mice. This suggests a complex interaction between these receptors that may impact how these substances affect behavior.
Study at a glance
| Population | mice |
|---|---|
| Key finding | The α2-adrenergic receptor modulates 5-HT2A-mediated behavioral effects of MDMA and psilocybin. |
Abstract
α2-Adrenergic receptor modulates 5-HT2A-mediated behavioral effects of MDMA and psilocybin in mice.