Mystical Experiences as Catalysts in Ketamine-Assisted Psychotherapy: A Case Study
Miguel Joaquim Soares Teles Couceiro, Victor José da Conceição Teixeira Amorim Rodrigues, Nuno Manuel Correia Torres
Journal of Psychoactive Drugs July 3, 2026 Peer reviewed DOI: 10.1080/02791072.2026.2696253 via OpenAlex
Summary
Mystical-type experiences during ketamine-assisted psychotherapy (KAP) may enhance therapeutic outcomes for patients with generalized anxiety disorder. A patient underwent four KAP sessions, and improvements were linked to higher scores on the Hood Mysticism Scale. The patient noted that the psychological and spiritual aspects of these experiences, along with the therapeutic relationship and integration process, contributed significantly to their progress. This suggests that subjective experiences can be important in KAP's effectiveness.
Study at a glance
| Design | case study |
|---|---|
| Sample size | 1 |
| Population | a patient with generalized anxiety disorder and migraines |
| Key finding | Higher scores on the Hood Mysticism Scale were associated with greater therapeutic gains in ketamine-assisted psychotherapy. |
Abstract
This case study explores the potential role of mystical-type experiences in ketamine-assisted psychotherapy (KAP). A patient with generalized anxiety disorder and migraines underwent four intramuscular KAP sessions (0.5-0.9 mg/kg). Outcomes were assessed using the Outcome Questionnaire-45 (OQ-45), the Hood Mysticism Scale (HMS), and interviews. Greater therapeutic gains followed sessions with higher HMS scores. The patient attributed improvements to the psychological and spiritual impact of the experiences, emphasizing the therapeutic relationship and integration process. In this case, these experiences appeared to play a meaningful role in therapeutic change, contributing to the discussion on the role of subjective effects in KAP.