Neuroestimulantes naturales: de rituales ancestrales a terapias de vanguardia
Armando Ordaz‐hernández, M. Corona-ramírez, Israel Jesús Orlando Guerrero
Revista CienciaUANL July 1, 2026 Peer reviewed DOI: 10.29105/cienciauanl29.138-5 via OpenAlex
Summary
Psilocybin and 5-MeO-DMT have been used in spiritual rituals in Mexico and are now recognized as promising therapies for depression, anxiety, PTSD, and treatment-resistant addictions. They function by acting on serotonin receptors and promoting neuroplasticity, which helps individuals adapt and overcome negative mental patterns. More clinical studies are necessary to further explore their potential, but their historical use informs modern therapeutic approaches that blend traditional practices with scientific insights.
Study at a glance
| Key finding | Psilocybin and 5-MeO-DMT are identified as promising therapies for various mental health issues, acting on serotonin receptors and enhancing neuroplasticity. |
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Abstract
La psilocibina, presente en los “hongos mágicos”, y la 5-MeO-DMT, secretada por el sapo Incilius alvarius, fueron empleadas ancestralmente en rituales espirituales en México. Hoy, la ciencia las reconoce como terapias prometedoras contra depresión, ansiedad, estrés postraumático y adicciones resistentes a tratamientos convencionales. Actúan sobre receptores de serotonina y estimulan la neuroplasticidad, favoreciendo la adaptación y la superación de patrones mentales negativos. Aunque se requieren más estudios clínicos, su uso ancestral inspira terapias innovadoras que integran tradición y ciencia para mejorar el bienestar emocional (Kishon et al., 2024). Abstract Psilocybin, found in “magic mushrooms,” and 5-MeO-DMT, secreted by the Incilius alvarius toad, were ancestrally used in spiritual rituals in Mexico. Today, science recognizes them as promising therapies for depression, anxiety, post-traumatic stress disorder, and addictions resistant to conventional treatments. They act on serotonin receptors and stimulate neuroplasticity, promoting adaptation and the overcoming of negative mental patterns. Although further clinical studies are needed, their ancestral use inspires innovative therapies that integrate tradition and science to improve mental health (Kishon et al., 2024).