Music Playlist Use in Clinical Trials of Psychedelic Assisted Psychotherapy: A Systematic Review
Lucas Cruz, Fernando R. Beserra, Julia M.k. Freind, Sandro E. Rodrigues, Daniel C. Mograbi
Journal of Clinical Psychology June 15, 2026 Peer reviewed DOI: 10.1002/jclp.70167 via OpenAlex
Summary
Psychedelics, particularly psilocybin and MDMA, show promise in treating psychiatric disorders, with music playing a significant role in enhancing the therapeutic experience. This systematic review examined 36 articles, finding that 25 discussed music use in psychedelics-assisted psychotherapy (PAP), mainly for depressive disorders and PTSD. There was notable variation in music selection and protocols among studies, highlighting the need for standardized approaches to optimize therapeutic outcomes.
Study at a glance
| Design | systematic review |
|---|---|
| Population | psychedelics-assisted psychotherapy studies focusing on depressive disorders and PTSD |
| Key finding | The review found considerable variation in music selection and procedures across studies utilizing psychedelics for therapy. |
Abstract
Recent studies have shown promising results for psychedelics in the treatment of psychiatric disorders. Both in clinical and recreational settings, contextual elements, such as music, can influence the experience of users and may be linked to positive outcomes. This systematic review identifies how music is being selected and used in psychedelisc-assisted psychotherapy (PAP). The search adopted PRISMA criteria and was conducted using PubMed, PsycNet, Web of Science, Scopus and Cochrane as databases. The use of music in PAP was compared, considering aspects such as the creation of a playlist, playlist features and characteristics of the setting. A total of 36 articles were found, with 25 articles mentioning the use of music, predominantly addressing depressive disorders and post-traumatic stress disorder using psilocybin and 3,4-methylenedioxymethamphetamine (MDMA). There was considerable variation in terms of procedures, mostly because studies explored different disorders and substances, but also because there was no standardized protocol regarding music. Understanding which aspects are being privileged when choosing music for use in PAP may orient future clinical and research efforts.