PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under Psilocybin.
Leonardo Novelli, Devon Stoliker, Tamrin Barta, Matthew D Greaves, Sidhant Chopra, James Jackson, Jessica Kwee, James C Pang, Martin L Williams, Adeel Razi
Scientific data May 21, 2026 Peer reviewed DOI: 10.1038/s41597-026-07312-1 via PubMed
Summary
PsiConnect is a neuroimaging study involving 62 participants that explores the effects of a 19 mg dose of psilocybin on brain activity and subjective experiences. The study incorporates various imaging techniques, including fMRI and EEG, and examines conditions such as guided meditation and music listening. Participants also underwent an 8-week meditation training program. This comprehensive approach allows for in-depth analysis of psilocybin's impact on brain function and behavior over time.
Study at a glance
| Sample size | 62 |
|---|---|
| Population | participants receiving psilocybin |
| Key finding | The study aims to investigate the context-dependent neural and subjective effects of psilocybin using multimodal neuroimaging techniques. |
Abstract
PsiConnect is a large-scale neuroimaging study designed to investigate context-dependent neural and subjective effects of psilocybin using multimodal neuroimaging. It combines functional, structural, and diffusion-weighted MRI with EEG to examine brain activity in 62 participants before and after a 19 mg dose of psilocybin. The design includes resting-state scans and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the cohort underwent an 8-week meditation training program, enabling exploration of interactions among meditation, psilocybin, and brain function. fMRI data was obtained through multi-echo fMRI, enhancing signal-to-noise ratio and reducing susceptibility artifacts to improve reliability. A comprehensive battery of behavioural and self-report measures captured acute and longitudinal cognitive and subjective effects, with follow-ups to one year post-administration. The large sample, multimodal imaging, contextual diversity, and behavioural follow-ups enable study of psilocybin-induced brain and behaviour changes with unprecedented comprehensiveness and reliability. Data is curated according to open science principles to ensure accessibility and compatibility with established neuroimaging pipelines, making PsiConnect a valuable, reusable resource for cognitive and computational neuroscience.