Sustained Effects of Low-to-Moderate Doses of Psilocybin on Brain Connectivity
Chiranth Bhagavan, Orwa Dandash, Olivia Carter, Alexander Bryson, Richard A. Kanaan
medRxiv Preprint Server April 17, 2026 preprint DOI: 10.64898/2026.04.17.26351147 via medRxiv
Summary
Psilocybin, a classic psychedelic, significantly alters brain functional connectivity, particularly at therapeutic doses. While some changes in connectivity have been observed to persist beyond the immediate effects of the drug, the impact of lower doses on sustained connectivity changes is not well understood.
Study at a glance
| Key finding | The effects of lower doses of psilocybin on sustained connectivity changes remain unclear. |
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Abstract
Background Psilocybin is a classic psychedelic that acutely alters brain functional connectivity. These changes are linked to therapeutic doses and subjective effects, with some evidence that changes persist beyond acute drug administration. However, the effects of lower doses on sustained connectivity changes remain unclear.