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These aren’t the beliefs you’re looking for: on the limits of affect-neutral accounts of psychedelic therapy

Celia R. Blaise

Synthese January 26, 2026 Peer reviewed DOI: 10.1007/s11229-026-05443-x via OpenAlex

Summary

The subjective intensity and quality of psychedelic experiences are more important for therapeutic outcomes than the dosage used. While many theories suggest that belief disruption or expanded awareness contributes to these benefits, it is argued that such changes alone do not explain why the effects are generally positive. Without a positive shift in emotional state, it remains unclear why these experiences would be beneficial rather than harmful.

Study at a glance

Key finding Without a positive shift in affective valence, there is no clear reason why psychedelic experiences should lead to therapeutic outcomes.

Abstract

Abstract A recurring finding in psychedelic-assisted therapy is that the subjective intensity and quality of the psychedelic experience contribute more to therapeutic outcomes than the administered dose. To explain why such experiences are therapeutic, many have appealed to what these may reveal or enable, such as the types of mental representations that can be acquired, the expansion of what can enter awareness, or the revision of high-level beliefs about the self and the world. Across these proposals, some form of belief disruption is often assigned a causal role. In this paper, I argue that even if psychedelics do work by loosening beliefs or expanding awareness, this alone is not sufficient to explain why the resulting changes should be beneficial rather than neutral or harmful. By implicitly taking for granted the typically positive character of many psychedelic experiences, existing theories risk describing processes that could just as easily worsen distress as alleviate it, and so fail to reflect the literature’s predominantly positive outcomes. Ultimately, I argue that without a positive shift in affective valence, there is no clear reason why psychedelic experiences should lead to therapeutic outcomes.

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