Apical regional wall motion abnormalities reminiscent to Tako-Tsubo cardiomyopathy following consumption of psychoactive fungi.
Holger M Nef, Helge Möllmann, Pirmin Hilpert, Nicola Krause, Christian Troidl, Michael Weber, Andreas Rolf, Thorsten Dill, Christian Hamm, A Elsässer
International journal of cardiology May 1, 2009 Peer reviewed DOI: 10.1016/j.ijcard.2007.12.064 via PubMed
Summary
A young male patient experienced acute coronary syndrome with significant ST-elevation after using magic mushrooms. Coronary angiography ruled out relevant coronary artery disease, and cardiac imaging showed no signs of myocardial infarction. The patient's ventricular function returned to normal within several days. The effects of psilocybin, the active compound in these fungi, may lead to contractile dysfunction similar to Tako-Tsubo cardiomyopathy.
Study at a glance
| Sample size | 1 |
|---|---|
| Population | a young male patient |
| Key finding | The patient showed contractile dysfunction reminiscent of Tako-Tsubo cardiomyopathy after consuming psychoactive fungi, but ventricular function normalized within several days. |
Abstract
Consumption of natural hallucinogenic substances continues to be a problem. In this case we report from a young male patient presenting with an acute coronary syndrome with significant ST-elevation after the abuse of psychoactive fungi, commonly referred to as "magic mushrooms". Coronary angiography excludes relevant coronary artery disease. In ventriculography contractile dysfunction with hypokinesia in the apical segments could be documented reminiscent to wall motion abnormalities in Tako-Tsubo cardiomyopathy (TTC). Cardiovascular magnetic resonance imaging showed no pathological signal activity in the late-enhancement sequences ruling out myocardial infarction or inflammatory processes. Ventricular function normalized within several days. The active metabolite of psychoactive fungi psilocybin is known to interact with several different dopaminergic, adrenergic and serotonergic receptors. Thus, the pathomechanisms leading to contractile dysfunction after consumption of psychoactive fungi are reminiscent to those documented in TTC.