LSD

Summary

Albert Hofmann's discovery of LSD sparked significant changes in the pharmaceutical industry, prompting research into how chemical structures are recognized and how they trigger physiological responses. The potency of LSD challenged traditional models of enzyme action. The series includes discussions on Hofmann’s contributions to meditation, creativity, mental illness treatment, and the drug's recreational use, alongside a review of a commemorative publication for his 100th birthday.

Study at a glance

Abstract

Albert Hofmann’s discovery of LSD by “chance or by a higher plan” led to a revolution in the pharmaceutical industry, inspiring research to understand how a chemical’s structure is recognized and how this recognition triggers a physiological response. The incredible potency of this drug challenged the conventional lock-and-key model that Emil Fischer had proposed for enzymes. In fact, the astounding physiological properties of LSD may have overshadowed the scientific expertise and outstanding qualities of its discoverer, Albert Hofmann, who celebrated his 100th birthday this year. The first article in this series (pp 413-420) sketches Hofmann’s discovery of LSD, its use as an adjunct to meditation, creativity, and consciousness expansion, and treatment of the mentally ill as well as its abuse as a pleasure drug. The third article (pp 427-436) discusses Hofmann’s life and especially his chemistry and his passion for nature. We are also reviewing a Festschrift commemorating his centenary (pp 451-452).