Efficiency of Capillary Column Gas Chromatography in Separating Lysergic Acid Diethylamide (LSD) and Lysergic Acid Methylpropylamide (LAMPA)
Dt Stafford, Hs Nichols, Wh Anderson
Journal of Forensic Sciences January 1, 1984 Peer reviewed DOI: 10.1520/jfs11662j
Summary
The study presents an efficient method for separating lysergic acid diethylamide (LSD) from lysergic acid methylpropylamide (LAMPA) using methyl silicone fused silica capillary columns. This approach allows for routine chromatographic separation that is both time-effective and reliable, addressing a common question faced by forensic drug chemists in court regarding the identification of LSD samples.
Study at a glance
| Key finding | The use of methyl silicone fused silica capillary columns provides a powerful and flexible method for effectively separating LSD from LAMPA. |
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Abstract
Abstract A question frequently asked of forensic drug chemists when they go to court on lysergic acid diethylamide (LSD) cases is, “How do you know this sample was not lysergic acid methylpropylamide (LAMPA) instead of LSD?” There are chromatographic means of separating the two compounds, but some of these are not very chromatographically efficient and others require time-consuming preparation of the chromatographic system. The separation on methyl silicone fused silica capillary columns described here can be performed routinely in a very time effective manner. One of the more interesting aspects of this work is the efficiency of the capillary system in this application. This combined with the inertness of the fused silica column and injection port liner, makes a very powerful and flexible means for addressing the separation problem and providing an answer to the original question.