Understanding the effects of lysergic acid diethylamide and the importance of its prevention
Burak Okumuş, Ahmet Metin, İ. Afşin Kariper
Health Sciences Review August 12, 2023 Peer reviewed DOI: 10.1016/j.hsr.2023.100107 via DOAJ
Summary
Lysergic acid diethylamide (LSD) has been used for pleasure and spiritual purposes, and its addictive potential remains undecided. It is soluble in water, allowing for various administration forms. LSD is also explored for treating psychiatric disorders like depression and PTSD. The review covers LSD's physicochemical properties, pharmacokinetics, receptor interactions, effects on healthy subjects, and addiction prevention strategies.
Study at a glance
| Design | review |
|---|---|
| Key finding | The addictive potential of LSD is still uncertain, despite its extensive use for recreational and therapeutic purposes. |
Abstract
This review is on lysergic acid diethylamide (LSD), which has a halogenic effect and is addictive. Up to now, LSD has been used for pleasure-inducing or spiritual purposes. Since it is soluble in water, it can be administered in different forms. The final decision about whether it is addictive or not is undecided. The use of LSD is extensive and is also used for treating psychiatric disorders such as depression, post-traumatic stress disorder, and addiction. In this review, firstly, general information on LSD was explained. Then, its physicochemical properties (solubility, melting point, stability), pharmacokinetics, receptor interactions, mechanism of action, studies with healthy subjects (subjective effects, autonomic and endocrine effects, psychiatric effects), and preventive studies against addiction effects were discussed. Finally, there are recommendations for the use of LSD.