Effects of serotonergic psychedelics on synaptogenesis and immediate early genes expression – comparison with ketamine, fluoxetine and lithium
Yana Vella, Kateřina Syrová, Aneta Petrušková, Isis Koutrouli, Viera Kútna, Jan Pala, Marek Nikolič, Klára Šíchová, Vladimír Mazoch, Radek Jurok, Martin Kuchař, Zdeňka Bendová, Tomáš Páleníček
bioRxiv Preprint Server August 7, 2024 preprint DOI: 10.1101/2024.08.07.606965 via bioRxiv
Summary
Psychedelics may provide rapid and long-lasting antidepressant effects, likely due to neuroplasticity, although the specific molecular mechanisms are not yet understood.
Study at a glance
| Key finding | Psychedelics can induce rapid and long-lasting antidepressant effects. |
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Abstract
Background Recent evidence suggests that psychedelics are able to induce rapid and long-lasting antidepressant effects. The generally acknowledged explanation for these traits is the phenomenon of neuroplasticity, although exact underlying molecular mechanisms remain unclear.