Psychedelic research must be grounded in pharmacology
Nature Neuroscience December 24, 2025 Peer reviewed DOI: 10.1038/s41593-025-02186-9 via Springer Nature
Summary
Psychedelic science is expanding quickly and holds potential for new therapies, but there are challenges. Key issues include a failure to recognize the field's history and accomplishments, as well as a poor understanding of psychedelic pharmacology and 5-HT_2A receptors. Addressing these gaps is essential for responsible advancement in the field.
Study at a glance
| Key finding | The field of psychedelic science faces challenges that must be addressed for responsible advancement. |
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Abstract
Psychedelic science is growing rapidly and offers great promise for exciting new therapies, but this rapid growth has brought growing pains. These include a lack of appreciation of the history of the field and what has already been accomplished, and a lack of understanding of the pharmacology of psychedelics and 5-HT_2A receptors. These gaps must be recognized, acknowledged and addressed in order for the field to advance responsibly.