[Altered states of consciousness induced by N,N-dimethyltryptamine (DMT)].
P Bickel, A Dittrich, J Schoepf
Pharmakopsychiatrie, Neuro-Psychopharmakologie September 1, 1976 Peer reviewed DOI: 10.1055/s-0028-1094495 via PubMed
Summary
In a controlled study with 38 volunteers, administration of 250 mcg/kg N,N-Dimethyltryptamine (DMT) led to significant differences in altered states of consciousness compared to placebo. Participants reported visual hallucinations, memory and attention impairment, changes in body image, depersonalization, derealization, euphoric and anxious-depressive states, and delusions. The main somatic side effects included subjective respiratory troubles, dizziness, and weakness.
Study at a glance
| Design | controlled study |
|---|---|
| Sample size | 38 |
| Population | volunteers |
| Key finding | Significant differences in altered states of consciousness were found in subjects receiving DMT compared to those receiving placebo. |
Abstract
In a controlled study on 38 volunteers the effects of 250 mcg/kg N,N-Dimethyltryptamine (DMT) i.m. were assessed. 26 subjects received DMT and 12 placebo. The altered states of consciousness and the somatic changes were measured by several questionnaires administered after the experiment. In spite of the low dose as compared to previous studies significant differences to placebo were found in the following syndromes of altered states of consciousness: visual hallucinations rep. illusions, impairment of memory and attention, changes of body image, depersonalization syndrome, derealization syndrome, euphoric state, anxious-depressive state and delusion. The somatic side effects were mainly subjective respiratory troubles, dizziness and weakness.