Transient or transformative? Psychedelics, agency and informed consent
Journal of Medical Ethics March 10, 2026 Peer reviewed DOI: 10.1136/jme-2025-111248 via OpenAlex
Summary
Psychedelic experiences are often viewed as transformative, raising ethical concerns about the validity of informed consent in therapy. If these experiences can significantly change a person's values in ways they cannot anticipate, their consent may be questionable. However, this perspective may oversimplify the transformation process, which involves a subsequent sober and authentic engagement by patients. This two-step model suggests that informed consent can still be valid despite the initial altered state.
Study at a glance
| Key finding | The two-step view of psychedelic transformation suggests that informed consent remains valid even when initial experiences are profoundly altering. |
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Abstract
The literature on psychedelic experiences often highlights their transformative potential. This raises ethical questions about informed consent in psychedelic-assisted therapy: if the altered state of consciousness induced by psychedelic drugs can profoundly alter a person's value system in ways that are epistemically inaccessible to them beforehand, it is unclear whether their informed consent before the experience can be considered valid. I argue that this view stems from a simplistic understanding of psychedelic-mediated transformation, which overemphasises the power of the psychedelic experience in driving change. In most psychedelic-mediated changes, the experience of an altered state of consciousness is only the beginning of the transformative process: a lasting transformation requires patients to undertake a sober, authentic agential process following the psychedelic experience. I suggest that this two-step view of psychedelic transformation alleviates the pressure on informed consent.