Behavioral pharmacology of mescaline - the role of serotonin 5-HT2A, 5-HT2B, 5-HT2C and 5-HT1A receptors
Lucie Olejníková-Ladislavová, Michaela Fujáková-Lipski, Klára Šíchová, Hynek Danda, Kateřina Syrová, Jiří Horáček, Tomáš Páleníček
bioRxiv Preprint Server August 28, 2024 preprint DOI: 10.1101/2024.08.28.610032 via bioRxiv
Summary
Mescaline is a psychedelic compound that primarily interacts with serotonin receptors, particularly 5-HT2A/C, but also affects 5-HT1A and 5-HT2B receptors. The exact influence of these different serotonin receptor subtypes on mescaline's behavioral effects remains unclear.
Study at a glance
| Key finding | The precise role of different serotonin receptor subtypes in mescaline's behavioral pharmacology is not fully understood. |
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Abstract
Rationale Mescaline is a classical psychedelic compound with a phenylethylamine structure that primarily acts on serotonin 5-HT2A/C receptors, but also binds to 5-HT1A and 5-HT2B receptors. Despite being the first psychedelic ever isolated and synthesized, the precise role of different serotonin receptor subtypes in its behavioral pharmacology is not fully understood.