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Beyond Access: The SIGNAL Model of Internal Guidance in Psychedelic Preparation and Integration

Stacy Rush

Psychedelics July 1, 2026 Peer reviewed DOI: 10.1016/j.psyche.2026.100027 via OpenAlex

Summary

Psychedelic-assisted interventions show varying mental health outcomes, often due to individuals' difficulties in engaging with their emotional signals, particularly those affected by trauma. The SIGNAL Model introduces a framework for understanding emotions as adaptive signals that inform needs and behaviors. It emphasizes the importance of recognizing and responding to these signals during preparation and integration phases. Effective therapeutic outcomes are linked more to an individual's engagement with emotional processes than the psychedelic experience itself.

Study at a glance

Key finding Therapeutic outcomes from psychedelic experiences depend more on an individual's ability to engage with emotional signaling processes than on the content of the psychedelic experience.

Abstract

Despite promising outcomes for mental health conditions, psychedelic-assisted interventions yield variable post-experience outcomes. Existing preparation and integration models emphasize insight and meaning-making but give insufficient attention to the role of internal guidance in sustaining therapeutic gains. For individuals shaped by trauma or performance-based environments, emotional signaling processes are frequently suppressed or mistrusted, which may limit the capacity to interpret and respond to what emerges during and after psychedelic experiences. This paper introduces the SIGNAL Model: Sense, Interpret, Ground, Navigate, Align, Live, a principle-guided framework that conceptualizes emotions as adaptive physiological signaling mechanisms. Within the model, emotions function as embodied communication systems that convey information relevant to unmet needs, threats, values, relational boundaries, identity, and meaning-making. Preparation focuses on developing the capacity to recognize and engage with these signals, while integration focuses on understanding and responding to them in ways that support identity coherence and sustained behavioral change. Psychological distress is proposed to emerge when emotional signaling processes are chronically suppressed, overridden, or misinterpreted, limiting their capacity to guide adaptive behavior. Integration involves restoring the individual’s ability to receive, understand, and respond to these signals effectively. Therapeutic outcomes are therefore proposed to depend less on the content of the psychedelic experience itself than on an individual’s capacity to engage with these signaling processes as organizing rather than destabilizing influences. Five testable hypotheses are advanced to guide empirical investigation of integration processes. Clinical implications include assessing emotional awareness prior to psychedelic work and structuring integration around the development of skills that help individuals recognize, interpret, and respond to emotions as adaptive physiological signaling mechanisms.

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