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Toad psychedelic points to biological target for antidepressants

Nature May 8, 2024 Peer reviewed DOI: 10.1038/d41586-024-01296-x via Springer Nature

Summary

A hallucinogenic compound secreted by toads may have antidepressant effects by binding to a previously overlooked target in the brain. This research highlights the potential therapeutic benefits of psychedelics, suggesting they could play a role in treating depression.

Study at a glance

Key finding The compound exerts antidepressant effects by binding to an under-appreciated target in the brain.

Abstract

A hallucinogenic compound secreted by toads has served as a springboard for research into the therapeutic benefits of psychedelics. The findings suggest that these compounds exert antidepressant effects in part by binding an under-appreciated target in the brain. Research into a hallucinogenic compound secreted by a toad has cast light on the therapeutic effects of psychedelics.

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