Effect of duloxetine acute treatment against 3, 4 methylenedioxymethamphetamine-induced cognitive impairment and memory deficiency in male rats
Avicenna Journal of Neuro Psycho Physiology June 22, 2020 Peer reviewed DOI: 10.32592/ajnpp.2020.7.3.108
Summary
Duloxetine treatment in male rats countered the negative effects of MDMA on anxiety, cognition, and memory. Specifically, duloxetine reduced the time spent in open arms and target quadrant, indicating decreased anxiety and cognitive impairment. In tests like the Morris water maze and passive avoidance learning, duloxetine improved performance compared to those treated with MDMA alone. These results suggest that duloxetine may mitigate MDMA's adverse effects on learning and memory.
Study at a glance
| Design | experimental study |
|---|---|
| Population | male Wistar rats |
| Key finding | Duloxetine treatment attenuated the MDMA-induced anxiolytic response and improved cognitive impairment and disturbance in learning and memory. |
Abstract
Background and Aims: 3, 4- methylenedioxymethamphetamine (MDMA) is used for recreational purposes worldwide. The use of MDMA resulted in learning and memory dysfunction. Duloxetine, a serotonin/noradrenalin-reuptake inhibitor is also utilized to treat depression and anxiety. The current study aimed to evaluate the effects of duloxetine against MDMAchr('39')s effect on anxiety, cognition, and memory disturbance in the male rats. Materials and Methods: Wistar rats received treatment of saline (10 ml/kg; sham group), “MDMA” (10 mg/kg), “Duloxetine” (10 mg/kg), and Duloxetine plus MDMA (10 mg/kg, each), or no treatment (control) through the intraperitoneal administration for four days. The elevated plus maze (EPM), passive avoidance learning (PAL), Morris water maze (MWM), and novel object recognition (NOR) tests were employed to evaluate the anxiety, memory, and cognition, Results: The MDMA increased the time spent in open arms in EPM, time spent in the dark part of PAL, and swimming time to reach the platform in MWM. Furthermore, duloxetine inhibited the reduction of the discrimination index, time spent in the dark compartment, and time spent on the platform in NOR, PAL, and MWM tests among rats received MDMA. Moreover, duloxetine decreased time spent in open arms and the target quadrant in EPM and MWM tests. Conclusions: Our findings suggested that duloxetine treatment attenuated the MDMA-induced anxiolytic response and could improve MDMA-induced cognitive impairment and disturbance in learning and memory.