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Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats

bioRxiv July 1, 2026 Peer reviewed DOI: 10.64898/2026.06.26.734907

Summary

Acute ketamine treatment leads to long-term reductions in anxiety for female Wistar Kyoto rats, even though it increases oxidative stress levels. This suggests that ketamine may have beneficial effects on anxiety despite potential negative impacts on oxidative stress.

Study at a glance

Population female Wistar Kyoto rats
Key finding Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress.

Abstract

Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats

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