Unveiling the role of single versus repeated low-dose ketamine in attenuating doxorubicin-induced chemobrain and depression in rats: differential modulation of neuroinflammation, phosphorylated GLT-1, SERT, DAT, and BDNF/TrkB signaling.
Neuropharmacology June 1, 2026 Peer reviewed DOI: 10.1016/j.neuropharm.2026.111055 via PubMed
Summary
Single and repeated low doses of ketamine were examined for their effects on doxorubicin-induced chemobrain and depression in rats. The study highlights how these treatments differentially affect neuroinflammation and key signaling pathways related to brain function, including GLT-1, SERT, DAT, and BDNF/TrkB. However, specific outcomes or quantitative results are not provided.
Study at a glance
| Population | rats |
|---|---|
| Key finding | Single and repeated low doses of ketamine differentially modulate neuroinflammation and various signaling pathways related to chemobrain and depression. |
Abstract
Unveiling the role of single versus repeated low-dose ketamine in attenuating doxorubicin-induced chemobrain and depression in rats: differential modulation of neuroinflammation, phosphorylated GLT-1, SERT, DAT, and BDNF/TrkB signaling.