Structural Neurotoxic and Neuroprotective Effects of Ketamine and Esketamine in Preclinical and Human Studies: A Systematic Review
Research Square May 27, 2026 Peer reviewed DOI: 10.21203/rs.3.rs-9827580/v1
Summary
The systematic review evaluates the structural neurotoxic and neuroprotective effects of ketamine and esketamine, analyzing both preclinical and human studies. It highlights that while these substances may exhibit neuroprotective properties, there are also indications of potential neurotoxicity in certain contexts. The findings suggest a complex relationship between ketamine, esketamine, and brain structure, necessitating further investigation.
Study at a glance
| Design | systematic review |
|---|---|
| Key finding | Ketamine and esketamine may have both neuroprotective and neurotoxic effects, indicating a complex relationship with brain structure. |
Abstract
Structural Neurotoxic and Neuroprotective Effects of Ketamine and Esketamine in Preclinical and Human Studies: A Systematic Review