Shorter to be effective: subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation.
Psychopharmacology (Berl) May 22, 2026 Peer reviewed DOI: 10.1007/s00213-026-07089-6 via PubMed
Summary
Subanesthetic-dose ketamine infusion decreases both global and regional brain functional connectivity path lengths in patients suffering from treatment-resistant depression and suicidal ideation. This suggests that shorter ketamine treatments can be effective in altering brain connectivity associated with these conditions.
Study at a glance
| Population | patients with treatment-resistant depression and suicidal ideation |
|---|---|
| Key finding | Subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity. |
Abstract
Shorter to be effective: subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation.