Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder.
Transl Psychiatry May 29, 2026 Peer reviewed DOI: 10.1038/s41398-026-04133-z via PubMed
Summary
The modulation of negative affective biases by NMDA antagonists in male rats could predict their clinical effectiveness for treating major depressive disorder. This suggests that understanding these differences might help in developing more effective treatments for this condition.
Study at a glance
| Population | male rats |
|---|---|
| Key finding | Differences in NMDA antagonists' effects on negative affective biases may predict their clinical efficacy in major depressive disorder. |
Abstract
Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder.