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Variability in the effects of ketamine enantiomers across animal models of depression and implications for human studies.

Br J Pharmacol June 16, 2026 Peer reviewed DOI: 10.1111/bph.70541 via PubMed

Summary

The effects of ketamine enantiomers on depression show variability across different animal models, which may have implications for their use in human studies. Understanding these differences is crucial for translating findings from animal research to clinical applications.

Study at a glance

Key finding Ketamine enantiomers exhibit variable effects on depression in animal models.

Abstract

Variability in the effects of ketamine enantiomers across animal models of depression and implications for human studies.

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