Astrocytic μ-δ opioid receptor heterodimers mediate the antidepressant effects of ketamine’s metabolite
bioRxiv June 3, 2026 Peer reviewed DOI: 10.64898/2026.05.31.727553
Summary
Astrocytic μ-δ opioid receptor heterodimers play a role in mediating the antidepressant effects of a metabolite of ketamine. This suggests that these specific receptors are involved in the mechanism through which ketamine's metabolite exerts its benefits for depression.
Study at a glance
| Key finding | Astrocytic μ-δ opioid receptor heterodimers mediate the antidepressant effects of ketamine’s metabolite. |
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Abstract
Astrocytic μ-δ opioid receptor heterodimers mediate the antidepressant effects of ketamine’s metabolite