A comparison of the antianhedonic effects of repeated ketamine infusions in melancholic and non-melancholic depression
Wei Zheng, Xin-Hu Yang, Li-Mei Gu, Jian-Qiang Tan, Yan-Ling Zhou, Cheng-Yu Wang, Yu-Ping Ning
Frontiers in Psychiatry December 22, 2022 Peer reviewed DOI: 10.3389/fpsyt.2022.1033019 via DOAJ
Summary
Patients with melancholic depression showed a non-significant lower response to ketamine infusions compared to those with non-melancholic depression, with 43.3% versus 50.5% experiencing an improvement in anhedonic symptoms. However, both groups had similar efficacy from the treatment, and the melancholic group had significantly lower anhedonia scores at day 26. Overall, six ketamine infusions improved anhedonic symptoms in both groups.
Study at a glance
| Design | clinical trial |
|---|---|
| Sample size | 135 |
| Population | patients with melancholic and non-melancholic depression |
| Key finding | Melancholic depression had a non-significant lower antianhedonic response to ketamine compared to non-melancholic depression. |
Abstract
ObjectivesMelancholic depression may respond differently to certain treatments. The aim of this study was to compare the antianhedonic effects of six intravenous injections of 0.5 mg/kg ketamine in patients with melancholic and non-melancholic depression, which remain largely unknown.MethodsIndividuals experiencing melancholic (n = 30) and non-melancholic (n = 105) depression were recruited and assessed for anhedonic symptoms using the Montgomery–Åsberg Depression Rating Scale (MADRS). The presence of melancholic depression was measured with the depression scale items at baseline based on DSM-5 criteria.ResultsA total of 30 (22.2%) patients with depression fulfilled the DSM-5 criteria for melancholic depression. Patients with melancholic depression had a non-significant lower antianhedonic response (43.3 vs. 50.5%, t = 0.5, p > 0.05) and remission (20.0 vs. 21.0%, t = 0.01, p > 0.05) to repeated-dose ketamine infusions than those with non-melancholic depression. The melancholic group had significantly lower MADRS anhedonia subscale scores than the non-melancholic group at day 26 (p < 0.05).ConclusionAfter six ketamine infusions, the improvement of anhedonic symptoms was found in both patients with melancholic and non-melancholic depression, and the efficacy was similar in both groups.