Mania following ketamine abuse.
Yuan-yuan Lu, Chieh-hsin Lin, Hsien-Yuan Lane
Neuropsychiatric disease and treatment January 1, 2016 Peer reviewed DOI: 10.2147/ndt.s97696 via PubMed
Summary
A 26-year-old man who abused ketamine by inhalation for 12 months developed manic-like symptoms. This case suggests a possible relationship between ketamine abuse and the onset of mania, marking it as potentially the first report of such symptoms following recreational ketamine use.
Study at a glance
| Design | case study |
|---|---|
| Sample size | 1 |
| Population | a 26-year-old man who abused ketamine |
| Key finding | The case indicates a possible relationship between manic symptoms and ketamine abuse. |
Abstract
Ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, has multiple clinical uses. On the other hand, ketamine abuse or recreational use has been gaining increasing attention. Induction of mania and psychotic symptoms has been reported in a patient receiving IV ketamine therapy for reflex sympathetic dystrophy. We here report a 26 year-old man who abused ketamine by inhalation for 12 months and developed manic-like symptoms after ketamine use. This case suggests a possible relationship between manic symptoms and ketamine abuse. To the best of our knowledge, this may be the first report regarding mania after recreational use of ketamine.