Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol.
Contemp Clin Trials March 2, 2026 Peer reviewed DOI: 10.1016/j.cct.2026.108273 via PubMed
Summary
The EQUIVALENCE trial protocol outlines a study comparing the effectiveness of intravenous ketamine to intranasal esketamine in treating patients with treatment-resistant depression. The goal is to determine if intravenous ketamine is non-inferior to intranasal esketamine in terms of efficacy for this patient group.
Study at a glance
| Design | comparative effectiveness study |
|---|---|
| Population | patients with treatment-resistant depression |
Abstract
Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol.