Postmarketing Safety Concerns With Esketamine: A Disproportionality Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System
May 25, 2021 DOI: 10.64239/pi-qt2702
Summary
Esketamine is associated with a higher likelihood of causing suicidal ideation compared to venlafaxine. Additionally, the induction of mania occurs more frequently with esketamine, and there are indications that it may induce euphoric mood, which raises concerns about its potential for abuse. Caution is advised when using this medication.
Study at a glance
| Key finding | Esketamine is more likely than venlafaxine to cause suicidal ideation and has a higher incidence of inducing mania. |
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Abstract
Esketamine appears more likely than venlafaxine to cause suicidal ideation. Induction of mania was more common than with venlafaxine. Induction of euphoric mood suggests abuse potential. Caution is warranted.