Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe.
Eva Garrido, María Alfonso, Borja Díaz de Greñu, Beatriz Lozano-torres, Margarita Parra, Pablo Gaviña, M Dolores Marcos, Ramón Martínez-máñez, Félix Sancenón
Chemistry (Weinheim an der Bergstrasse, Germany) March 2, 2020 Peer reviewed DOI: 10.1002/chem.201905688 via PubMed
Summary
A hybrid nanodevice was developed for detecting the drug 25I-NBOMe using mesoporous silica nanoparticles. The device releases a fluorescent dye when 25I-NBOMe is present, due to the displacement of an antibody that caps the pores. This system can detect 25I-NBOMe at a limit of 0.6 μM and does not respond to other drugs like cocaine or heroin, demonstrating its sensitivity and selectivity in artificial saliva and sweets.
Study at a glance
| Key finding | The nanodevice allows for sensitive detection of 25I-NBOMe at a limit of 0.6 μM, with no interference from other common drugs. |
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Abstract
This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5-HT2A receptor antibody. In the presence of 25I-NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5-HT2A receptor antibody detachment from the surface due to its stronger coordination with 25I-NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 μm) and selective recognition of the 25I-NBOMe drug (cocaine, heroin, mescaline, lysergic acid diethylamide, MDMA, and morphine were unable to induce pore opening and rhodamine B release). This nanodevice acts as a highly sensitive and selective fluorometric probe for the 25I-NBOMe illicit drug in artificial saliva and in sweets.