NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS
R. Shafik, N. Eshba, M. El-semary, M. Abdel-kreem
Bulletin of Pharmaceutical Sciences. Assiut University May 26, 2026 Peer reviewed DOI: 10.21608/bfsa.1994.69795 via DOAJ
Summary
The study discusses the synthesis of novel structural hybrids combining mescaline and PCP-analogs, aimed at exploring their potential antagonistic activity at central PCP-receptors in albino rat brains. The compounds include various chemical modifications such as 1-aryl-1-(3,4,5-trimethoxy or trihydroxy) phenethylamino and N-substituted-phenethylamino cycloalkanes, with some derivatives incorporating an N-(2-chloroethyl) moiety for further investigation.
Study at a glance
| Population | albino rat brains |
|---|---|
| Key finding | The effects of mescaline and the newly proposed derivatives on PCP-receptors are yet to be investigated. |
Abstract
The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs. The effect of mescaline and the potential antagonisticactivity of the newly proposed derivatives at central PCP-receptors of albino rat brains will await investigation. The suggested compounds were chemically 1-aryl-1-(3,4,5-trimethoxy; or trihydroxy) phenethylamino; or N-substituted-phenethylamino cycloalkanes. An N-(2-chloroethyl) moiety was, also incorporated into some of the designed analogs for exploration of the possible participation of such alkylating arm to the elicited activity.