The identification of LSD-like hallucinogens using the chronic spinal dog.

Summary

Psilocin, mescaline, dimethyltryptamine, and tryptamine exhibit LSD-like effects in chronic spinal dogs. DOM, DOB, DMA, and TMA are primarily LSD-like but also show some amphetamine-like activity. PMA and PEA are mainly amphetamine-like with some LSD-like effects. MMDA and MDA display complex pharmacology with properties resembling both LSD and amphetamine while also having unique actions. The study compared these substances to standard drugs like LSD and amphetamine.

Study at a glance

Abstract

The effects of several indoleamines and phenethylamines were studied in the chronic spinal dog and compared with two standard drugs, LSD and amphetamine. In the nontolerant chronic spinal dog, their effects on a variety of physiologic and behavioral functions were measured in untreated dogs, as well as dogs treated with certain antagonists. The effects of the antagonists phenoxybenzamine and cyproheptadine on the various physiologic effects were studied for all drugs. For some idoleamines and phenethylamines, the effects of chlorpromazine and pimozide were also studied. Indoleamines and phenethylamines in the LSD-tolerant chronic spinal dog and their anorexigenic effects in the intact dog were also studied. The results of these studies indicate that psilocin, mescaline, dimethyltryptamine and tryptamine are LSD-like drugs. DOM, DOB, DMA, and TMA are predominantly LSD-like drugs but do have some amphetamine-like action. PMA and PEA are predominantly amphetamine-like drugs with some LSD-like activity. MMDA and MDA have a more complicated pharmacology showing proerties that resemble LSD and amphetamine, but they have other actions which are not shared by either LSD or amphetamine, which suggests they have yet other modes of action.